Adrenalin or Epinephrin, the active principle of the medulla of the suprarenal gland, is employed as a chemical messenger in the regulation of the activities of the body; in fact, its presence is essential to the activity of the sympathetic nerve. Adrenalin action on any part is the same as stimulation of the sympathetic nerve endings thereto. Its action is very prompt, efficient, owing to rapid oxidation and therefore practically harmless.
Â Adrenalinum is a suitable remedy for debility. There is a sensation of constriction especially observed in stomach and intestines. Pulse is slow. It is also useful in contraction of muscular tissue of eye, uterus and vagina. It also helps in congestions of sinuses hence useful in hay fever.Â
Its chief therapeutic use depends on its vaso-constriction (constriction of blood vessels) action; therefore a most powerful and prompt astringent (cause contraction of tissues) and haemostatic (stops internal bleeding); and invaluable in atheroma (deposit in arteries) and heart lesions also very helpful checking capillary haemorrhages, from all parts, where local or direct application is feasible : nose, ear, mouth, throat, larynx, stomach, rectum, uterus, bladder. Hemorrhagic condition not due to defective coagulation of the blood. Complete bloodlessness, ischaemia (restriction in blood supply to tissues), may be induced with impunity. Locally, solutions [1 : 10,000-1 : 1,000] sprayed or applied on cotton have been very efficient in bloodless operations about the eye, nose, throat, and larynx.
Congestions of the ethmoid and sphenoid sinuses, also hay fever, have been markedly alleviated by warm spray of Adrenalin chloride, 1 : 5,000. Externally, it has been used in neuritis, neuralgia, reflex pains, gout, rheumatism, as an ointment, 1-2 m. of (1 : 1,000) solution.
Therapeutically, Adrenalin has been suggested in acute congestion of lungs, Asthma, Grave's and Addison's diseases, arterio-sclerosis, chronic aortitis, angina pectoris, haemophilia chlorosis, hay fever, serum rashes, acute urticaria, etc. The symptom guiding to this is, Sensation of thoracic constriction with anguish.